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KMID : 0981820110310020086
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Korean Journal of Laboratory Medicine
2011 Volume.31 No. 2 p.86 ~ p.90
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A Rare Case of Microgranular Acute Promyelocytic Leukemia Associated with ider(17)(q10)t(15;17) in an Old-age Patient
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Kim Min-Jin
Cho Sun-Young
Lim Ga-Young
Yoon Hoi-Soo
Lee Hee-Joo
Suh Jin-Tae
Lee Ju-Hie
Lee Woo-In
Cho Kyung-Sam
Park Tae-Sung
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Abstract
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We present a rare case of microgranular variant acute promyelocytic leukemia (APL) associated with ider(17)(q10)t(15;17)(q22;q12) of an old-age patient. The initial chromosome study showed a 46,XX,del(6)(?q21q25),der(15)t(15;17)(q22;q12),ider(17)(q10)t(15;17) [10]/47,sl,+ider(17)(q10)t(15;17)[3]/46,XX[16]. FISH signals from a dual color dual fusion translocation PML-RARA probe were consistent with the results of conventional cytogenetics. Because of the rarity of ider(17)(q10)t(15;17) in microgranular APL, further studies on both gene dosage effect of this chromosomal abnormality and the influence of ider(17)(q10)t(15;17) on clinical features such as prognosis, survival, and treatment response of APL cases are recommended.
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KEYWORD
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ider(17)(q10)t(15, 17), Old-age, Microgranular, Acute promyelocytic leukemia
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